Медицинские и биологические науки

Представители рода Rickettsia — мелкие плеоморфные грамотрицательные бактерии. Облигатный характер внутриклеточного паразитизма риккетсий требует использования биологических моделей для их изоляции и культивирования. Задача первой части обзора — представить информацию о возможностях применения (достоинства и ограничения) следующих биологических моделей: морские свинки, мыши, сирийские золотистые хомяки, куриные эмбрионы, используемых для изучения риккетсий. Данные модели наиболее адекватны для работы с «классическими» патогенными риккетсиями: Rickettsiа. rickettsii, R. conorii, R. sibirica, но не являются оптимальными для культивирования ряда новых представителей рода Rickettsia. Во второй части обзора планируется изложение характеристик клеточных культур и лабораторных линий иксодовых клещей в качестве биологических моделей в риккетсиологии.

Abstracts

The representatives of the genus Rickettsia are small pleomorphic gram-negative bacteria. The obligate nature of intracellular parasitism of Rickettsia requires using of biological models for their isolation and cultivation. The objectives of the first part of the review are to provide information on the possibilities of application (advantages and limitations) of the following biological models: guinea pigs, mice, Syrian golden hamsters, and chicken embryos, using for study Rickettsia. These models are most adequate for working with classical pathogenic rickettsia: R. rickettsii, R. conorii, R. sibirica, but are not optimal for culturing a number of new representatives of the genus Rickettsia. The second part of the review plans to present the characteristics of cell cultures and laboratory lines of ixodid ticks as biological models in rickettsiology.

Ирина Евгеньевна Самойленко - доктор медицинских наук, главный научный сотрудник лаборатории зоонозных инфекций Омского НИИ природно-очаговых инфекций; ORCID: https://orcid.org/ 0000-0002-2819-9280; eLibrary SPIN: 9691-4878; samoilenko.irinasamoylenko@yandex.ru.

About the authors

Irina Evgenievna Samoylenko — Doctor of Medical Sciences, Chief Researcher of the Laboratory of Zoonotic Infections of the Omsk Research Institute of Natural Focal Infections; ORCID: https://orcid.org/ 0000-0002-2819-9280; eLibrary SPIN: 9691-4878.

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